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  www.dicp.cas.cn    发布时间:2016-12-09    供稿部门:1810组、科技处
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报告题目:Biochemical Fractionation Strategy for Analysis of Protein Complexes Conserved across Metazoan

报告时间:20161210日(星期六)9:00-11:00

报告地点:生物楼学术报告厅

报告人:万翠红 教授

华中师范大学生命科学院副院长

    报告摘要:

    Knowledge of mutilprotein complexes is essential for understanding of biological processes, but their phylogenetic distribution across species, especially large-scale network mapping, is a challenge. Previous cross-species interactome comparisons, based on experimental data obtained from different sources and methods, typically show limited overlap. We examined comprehensive and accurate map of protein complexes common to metazoan by using a standardized approach, biochemical fractionation followed by quantitative mass spectrometry, to multiple species in parallel. In addition to human, 8 species were selected based on broad relevance as model organisms and breadth spanning a billion years of evolutionary divergence. We identified and quantified 13,386 protein orthologs across 6,387 fractions obtained from 69 different experiments, and final generate an interaction network consists of 16,655 high-confidenceco-complex interactions in human. Half of the predicted protein-protein interactions were supported by direct biochemical evidence in 3 or more input species, and half interactions have never been reported in any of five input species or yeast. Our study reveals the core physical underpinnings of the basic macromolecular machinery broadly relevant to metazoan physiology, development and evolution. The reconstructed interactome will provide rich functional insights into the fundamental molecular organization and evolutionary plasticity of animal cells.

    报告人简介:

    万翠红教授,华中师范大学生命科学学院副院长。20046月毕业于华中科技大学工程学院,获学士学位。20097月获中国科学院长春应用化学研究所博士学位。200910月至20147月,多伦多大学从事博士后研究。201410月至20156月,德州大学奥斯汀分校从事研究工作。201510月至今,担任华中师范大学生命科学学院副院长。 

    研究方向包括:不同蓝-绿藻种类中保留的共同蛋白质复合物;发菜中抗旱相关的蛋白质复合物;蛋白质和质谱分析新方法开发,包括蛋白质组学与生物质谱分析方法研究,包括高通量蛋白质复合物鉴定、高通量质谱数据分析、蛋白质相互作用网络分析、蛋白质翻译后修饰以及蛋白质靶向药物小分子筛选。

    报告联系人:1810组 张丽华(9720

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