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  www.dicp.cas.cn    发布时间:2016-10-28    供稿部门:1810组、科技处
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报告题目:Integrative Proteomics for Elucidating the Structure and Function of Cellular Machines

报告时间:20161031日(星期一)9:00-10:30

报告地点:生物楼学术报告厅

报告人:时毅 博士

洛克菲勒大学生物大分子质谱分析国家中心,质谱和气相离子化学实验室

    报告摘要:

  The extraordinarily emergent properties of living cells have evolved largely as a consequence of the intricately ordered interactions of their biomolecular components. These cellular building blocks (DNA, RNA, proteins, lipids etc.) interact with one another to form a hierarchy of dynamic, information-rich, macromolecular assemblies that drive a plethora of intriguing biological processes. Unfortunately, despite their central role in cell biology, the requisite structure-functional studies of endogenous multi-subunit macromolecular assemblies still prove to extraordinarily challenging-partially due to their low cellular abundance , dynamic nature, and heterogeneity of these native assemblies. 

    Over the years we have developed enabling integrative structural proteomic technologies to overcome these challenges. We have also applied these new tools to study the architectures and functions of large native macromolecular assemblies that regulate several fundamentally important processes of cell biology including DNA replication, basal gene transcription and its regulations. Most recently, we have begun to unravel the mechanistic details of the eukaryotic nuclear pore complex-the gigantic, ~500 protein machine that has been conserved for over a billion years of evolution, and the sole mediator for nuclear-cytoplasmic transport.

    报告人简介:

  时毅博士,就职于洛克菲勒大学生物大分子质谱分析国家中心、质谱和气相离子化学实验室。 

  时毅博士于2003年获得大连理工大学工学学士学位,2006年开始在贝勒医学院攻读并于2011年获得博士学位。2011-2014年在洛克菲勒大学从事博士后研究,2014-2016年在洛克菲勒大学任助理研究员,今年11月即将就任匹兹堡大学医学院细胞生物学系助理教授。 

    研究方向包括质谱学和蛋白质组学、综合结构生物学、基因损伤和细胞自噬及抗体和免疫学。目前已经在国际著名科学期刊如CellNature MethodsNature Structural Molecular BiologyMolecular & Cellular Proteomics等发表多篇研究文章。

   

    报告联系人:1810组 张丽华 研究员(9720

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